Membranous Nephrotic Syndrome

What is Membranous Nephrotic Syndrome? What’re the differences between Nephrotic Syndrome and Membranous Nephrotic Syndrome? Nephrotic Syndrome, as we know, is a group of renal glomerular disease, which is featured by a large amount of proteinuria, serious edema, hypoproteinemia and hyperlipemia, which in a conclusion we can call three high and one low for short. Nephrotic Syndrome, as we mentioned above, can be classified into primary Nephrotic Syndrome and secondary Nephrotic Syndrome. If patients with Diabetic Nephropathy which has developed into the fourth stage have a large amount of proteinuria, serious edema, hypoproteinemia and hyperlipemia, we can say they can also be diagnosed with secondary Nephrotic Syndrome. Diabetic Nephropathy is a clinical diagnosis which is termed according to the symptoms, indexes, and so on, while Nephrotic Syndrome is a pathological diagnosis, which is termed due to cytology.
So what’s is Membranous Nephrotic Syndrome? It is named according to cytology. When people feel discomfort and are diagnosed with Membranous Nephrotic Syndrome, they are so confused and wonder their real condition in detail. As a matter of fact, in recent years, the morbidity of Membranous Nephrotic Syndrome in increasing.
Membranous Nephrotic Syndrome, as its name implies, is a kind of primary Nephrotic Syndrome, which accounts for 10% of renal glomerular disease. Among adult Nephrotic Syndrome, Membranous Nephrotic Syndrome takes up 10% to 30%. Idiopathic membranous nephropathy for children is rarely seen. Membranous Nephrotic Syndrome can be found out in people with any age. Most of them begin with more than 35 years old. And the average age is 40 years. The onset climax is divided into two period: 30 to 40 years old and 50 to 60 years old.
Males who are diagnosed with Membranous Nephrotic Syndrome are more than women. 80% of patients with Membranous Nephrotic Syndrome have symptoms of Nephrotic Syndrome: a large amount of proteinuria, serious edema, hypoproteinemia and hyperlipemia. And 30% to 40% of them have microscopic hematuria and few of them have gross hematuria. Membranous Nephrotic Syndrome develops slowly, and it takes a long time for them to develop into renal failure. About 40% to 60% of them have renal vein thrombosis. At this stage, hormone and cytotoxic agents have no effect on it.
Generally, patients with Membranous Nephrotic Syndrome have no gross hematuria. Different from much acute infection nephritis, at the early stage of this disease, patients have no high blood pressure. However, with the disease developing, 30% to 50% will have high blood pressure. At the early stage, renal function of patients with Membranous Nephrotic Syndrome is normal. Several weeks or months after the onset, GFR(glomerular filtration rate)will decrease.
Normally, patients with Membranous Nephrotic Syndrome have no infection of upper respiratory tract. A few of patients have asymptomatic proteinuria. 70% to 80% of them have a large amount of proteinuria. The incubation period of Membranous Nephrotic Syndrome is generally several hours to several months.
From the above-mentioned, we can get a general idea about Membranous Nephrotic Syndrome. Once diagnosed with Membranous Nephrotic Syndrome, patients should receive treatment as early as possible.