The Pathogeny for Diabetic Nephropathy

The pathogeny for Diabetic Nephropathy(DN) generally include the following points:
1. Increase on Blood Viscosity and Obstruction on Microcirculation. Diabetes could arouse microangiopathy and often accompanied by the obstruction on microcirculation, which easily make the blood solidification and thrombosed. If there is thrombus in the microcirculation within kidney, the nephron would be hypoxic and ischemic, so the renal function decreases.
2. Hyperglycemia. Persistent hyperglycemia could develop into the hypertransfusion and hyper-filtration on glomerulus, thus make damage to ball mesangium, basement membrane and capillary endothelium, etc, which would make further impairment to glomerulus and kidney tubules. That factors triggering DN would eventually induce glomerulus atherosclerosis, thus cause the damage to nephron and arouse the renal dysfunction.
3. High Protein Diet. Protein-rich diet is also the factor that result DN. It would add burden to kidney and aggravate the proteinuria, which would form a vicious circle. So, daily intake for protein could no more than 40g.
4. Hyperlipaemia. Dyslipidemia is very common in the patients of diabetes. It can boost glomerulosclerosis and accelerate the progress of (Diabetic Nephropathy )DN.
5. Hypertension. Hypertension could make both the renal vascular resistance and the pressure inside kidney increased, and make the renal blood flow decreased, etc, which lead to proteinuria, glomerulosclerosis and renal failure. These are the factors for (Diabetic Nephropathy )DN.
6. Genetic Factor: Most diabetic patients would not have the kidney disease at last. However, some patients, who control the serum glucose very well for a long time, could also have an appearance of (Diabetic Nephropathy ) DN. Glucose transport protein-1(GLUT1) is the main transporter for glucose on glomerulus mesangial cells. This factor causing(Diabetic Nephropathy ) DN is more common.
7. Metabolic Disturbance
The clinical experimental researches indicate that, metabolic disturbance is the main factor that causes (Diabetic Nephropathy ) DN.
As a result of the continuous state of hyperglycemia resulted by lack of insulin, the disaccharide units that are formed by combining with galactose were increased, and meanwhile, along with the increase in the activity of glucose transfer on kidney, glycoprotein synthesis is increased and they deposit abundantly on basilemma. The hyperglycemia makes the HbA1c on glomerulus capillary basement membrane increased and influence the increase of connection permeability on polypeptide. As a result of the hypertrophy, proliferation and exudation of basilar membrane, microangiopathy is caused, which is also the common factor that result (Diabetic Nephropathy ) DN.
8. Endocrine Disorders
There is a close connection between secretion and the factors leading to (Diabetic Nephropathy )DN. Somatotropin could boost the protein synthesis and promote the synthesis and incrassation of basement membrane protein. Someone made a mouse involved in DN by injecting streptozocin(STZ) after cutting its hypophysis, and then gave it small doses somatotropin, the result is that its glomerulus basement membrane was significantly thickened, which illustrate that somatotropin is also one of the factors that lead to (Diabetic Nephropathy )DN.
The above are the explanations for (Diabetic Nephropathy )DN made by experts, we hope to help you. Here experts remind us, if anyone involve in any kind of disease, do not delay for a treatment, otherwise it would be very dangerous because some disease would worsen or trigger other disease and so on.