Creatinine is a kind of toxins coming into being in human body and should be discharged out of the body through the filtration of the kidney. So serum creatinine is an important index which can show the kidney function in some extent. Generally, the normal range of serum creatinine is 44 to 103 umol/L.
Low hemoglobin means low hemachrome, which is an important index which can judge whether people are in the insufficiency of anemia. Due to all kinds of factors, hemachrome is low in blood, which is called anemia. When serum creatinine is high, or when patients are suffering from kidney disease, patients can have low hemachrome. The detailed reasons are as follows:
Anemia caused by high creatinine or we can also say caused by kidney disease can be divided into the following cases.
1. the lack of EPO
More than 90% of EPO is generated in kidney tissues. There is no doubt that renal failure is the main reason which can cause anemia. Generally, the more serious the kidney is, the less EPO will be.
2. growth inhibitory factors of red blood cells
In uremia stage, there will be some materials which can inhibit the generation of red blood cells, which can influence the renal anemia. At present, it is thought that there are at least 4 kinds of inhibitory factors.
3.The lifespan of red blood cells is short.
At present, many researchers in kidney disease field have proved it in clinic. It is generally believed that the shortened lifespan of red blood cells is caused by factors out of cells sometimes.
4. loosing blood.
In the end stage of kidney disease, about 25% of chronic kidney disease patients will have obvious blood lost, which can worsen anemia. The main reason is that the function of blood cells is blocked, which leads to the bleeding in digestive tract and skin.
Very informative blogging, keep it up!
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