GFR and Kidney Function Test
Glomerular filtration rate (GFR) is the volume of fluid filtered from the renal glomerular capillaries into the Bowman's capsule per unit time. Glomerular filtration rate (GFR) can be calculated by measuring any chemical that has a steady level in the blood, and is freely filtered but neither reabsorbed nor secreted by the kidneys. The rate therefore measured is the quantity of the substance in the urine that originated from a calculable volume of blood. In a word, GFR is used to examine the kidney function.
Calculated or measured GFR or creatinine clearance has a normal range of 90-120 ml/min. For convenience, this is referred to as 100% of kidney function. For example, if GFR is 15ml/min, that is said to represent approximately 15% of kidney function. GFR (or creatinine clearance) varies with age. There is generally a slow decrease of about 1% of GFR/year from the mid thirties. So at age 70 years, GFR on average is often only 60-70% of the normal.
When there is damage in the kidney, GRF will decrease, the level of which can also divide chronic kidney disease into 5 stages. In stage 1, GFR is more than 90 ml/min. In stage 2, GFR is between 60 to 89 ml/min. In stage 3 of chronic kidney disease, GFR is 30 to 59 ml/min. In stage 4 of chronic kidney disease, GFR is 15 to 29 ml/min. In stage 5, GFR is less than 15 ml/min.
Glomerular filtration rate (GFR) is the volume of fluid filtered from the renal glomerular capillaries into the Bowman's capsule per unit time. Glomerular filtration rate (GFR) can be calculated by measuring any chemical that has a steady level in the blood, and is freely filtered but neither reabsorbed nor secreted by the kidneys. The rate therefore measured is the quantity of the substance in the urine that originated from a calculable volume of blood. In a word, GFR is used to examine the kidney function.
Calculated or measured GFR or creatinine clearance has a normal range of 90-120 ml/min. For convenience, this is referred to as 100% of kidney function. For example, if GFR is 15ml/min, that is said to represent approximately 15% of kidney function. GFR (or creatinine clearance) varies with age. There is generally a slow decrease of about 1% of GFR/year from the mid thirties. So at age 70 years, GFR on average is often only 60-70% of the normal.
When there is damage in the kidney, GRF will decrease, the level of which can also divide chronic kidney disease into 5 stages. In stage 1, GFR is more than 90 ml/min. In stage 2, GFR is between 60 to 89 ml/min. In stage 3 of chronic kidney disease, GFR is 30 to 59 ml/min. In stage 4 of chronic kidney disease, GFR is 15 to 29 ml/min. In stage 5, GFR is less than 15 ml/min.
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