How to Treat Lupus Nephritis with Immunotherapy
To know how to treat lupus nephritis, we should firstly figure out the
pathological mechanism of lupus nephritis. The main cause of this disease is
that when the body is infected by lupus cells, abnormal immune response exists
continuously and pathogenic autoantibody is produced, as a result, large amount
of immune complex, such as C3, IgG, IgM, etc. was generated in the blood, which
deposit at the glomerular epithelial cells, thus damaging the normal function of
the glomerular epithelial cells. In this case, proteins and red blood cells will
leak out through the pores of the basilar membrane, thus causing protein in
urine or hematuria in clinic.
It is an autoimmune disease. The regular medications are hormones and
immunosuppressive agents, which can indeed diminish the leaking out of protein
and red blood cells. However, after infection, protein in urine or blood urine
will come into being again. To treat lupus nephritis, the therapy should be
based on how it comes into being.
Immunotherapy is created in Eastern Greenland Hospital, which is a
combination of Chinese medicine and western medicine can be divided into 6
steps, immune diagnosis, immune clearance, immune blocking, immune tolerance,
immune regulation and immune protection.
1. immune diagnosis
After a systematic diagnosis, we can figure out where the immune complex
deposits exactly, the amount of immune complex so that doctors can get more
scientific diagnosis and arrange better treatment. Without it, we can not know
the dosage of medicine. Less dosage can not achieve the treatment effect while
too much can also cause damage to the kidney.
2. immune clearance
In immune clearance step, patients with lupus nephritis should clear away
the immune complex in the blood, which can supply a cleaner inner environment
for the treatment of kidney disease. For patients with SLE, the most proper
blood purification method is the plasma exchange. Pay attention that the immune
complex we clean is the one in the blood not the one on the kidney.
3. immune blocking
There is still immune complex which deposits onto kidney, which leads to
immune response and damage to the kidney cells and tissues. Medicine is used,
which can stop the excessive immune response, thus stopping the inflammation
response at a rapid speed.
4.immuen tolerance
The fourth one is immune tolerance. After immune blocking, the immune
response can be stopped. And the damage to the kidney can be blocked. However,
the immune complex still deposit onto the kidney, which leads to a new series of
immune response.
5. immune regulation
The fifth one is immune adjustment. In this step, Chinese medicines are
applied, which can improve the blood circulation, including micro-blood
circulation and dissolve the blood stasis. In this case, the immune complex can
be discharged out, and the immune system can be repaired. Note that in this
step, the immune complex we clean is the one on the kidney not the one in the
blood. Blood purification such as dialysis and plasma exchange can not achieve
this. In Eastern Greenland Hospital, we use Chinese Medicine. It can also repair
the damaged renal glomerular epithelial cells for it contains herbs and
nutritious materials.
6. immune protection
Last but not least, immune protection is applied, in which step, we use
medicine which can nourish qi and blood to rebuild the intrinsic immune system.
In addition, biochemical cell therapy is also used in clinic such as the
transplant of stem cell, which can also help enhance the immunity of lupus
nephritis patients. In this way, patients themselves can clear away the immune
complex in the blood and kidney, thus treating lupus nephritis from root.